Master donor viruses A/Leningrad/134/17/57 (H2N2) and B/USSR/60/69 and derived reassortants used in live attenuated influenza vaccine (LAIV) do not display neurovirulent properties in a mouse model
Identifieur interne : 000F88 ( Main/Exploration ); précédent : 000F87; suivant : 000F89Master donor viruses A/Leningrad/134/17/57 (H2N2) and B/USSR/60/69 and derived reassortants used in live attenuated influenza vaccine (LAIV) do not display neurovirulent properties in a mouse model
Auteurs : J. Theo [Pays-Bas] ; M. Voeten [Pays-Bas] ; Irina V. Kiseleva [Russie] ; Harrie L. Glansbeek [Pays-Bas] ; Stephanie M. C. Basten [Pays-Bas] ; Sandra K. M. Drieszen-Van Der Cruijsen [Pays-Bas] ; Larisa G. Rudenko [Russie] ; Han Van Den Bosch [Pays-Bas] ; Jacco G. M. Heldens [Pays-Bas]Source :
- Archives of virology [ 0304-8608 ] ; 2010.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Vaccin.
English descriptors
Abstract
Demonstration of the absence of neurovirulent properties of reassortant viruses contained in live attenuated influenza vaccine (LAIV) is a regulatory requirement. A mouse model was used to detect neurovirulent properties of the cold-adapted, temperature-sensitive and attenuated influenza master donor viruses (MDVs) A/Leningrad/134/ 17/57 (H2N2) and B/USSR/60/69 and derived reassortant influenza viruses. A/NWS/33 (H1N1), which is known to be neurovirulent in mice, was used as a positive control. Under conditions where the positive control virus induced symptoms of disease and showed viral replication in the upper respiratory tract as well as in the brain, replication of the influenza master donor viruses and reassortant influenza A and B viruses was limited to the upper respiratory tract where they were administered. None of the mice inoculated with MDVs or reassortant influenza viruses suffered from disease, and no virus or viral replication was observed in the brains of these mice. The results demonstrate the absence of neurovirulent properties of the MDVs and reassortant influenza viruses derived therefrom used in LAIV.
Affiliations:
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Theo</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Nobilon Schering-Plough, Wim de Körverstraat 35</s1><s2>5831 AN Boxmeer</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>5831 AN Boxmeer</wicri:noRegion></affiliation></author><author><name sortKey="Voeten, M" sort="Voeten, M" uniqKey="Voeten M" first="M." last="Voeten">M. Voeten</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Nobilon Schering-Plough, Wim de Körverstraat 35</s1><s2>5831 AN Boxmeer</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>5831 AN Boxmeer</wicri:noRegion></affiliation></author><author><name sortKey="Kiseleva, Irina V" sort="Kiseleva, Irina V" uniqKey="Kiseleva I" first="Irina V." last="Kiseleva">Irina V. 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Basten</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Nobilon Schering-Plough, Wim de Körverstraat 35</s1><s2>5831 AN Boxmeer</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>5831 AN Boxmeer</wicri:noRegion></affiliation></author><author><name sortKey="Drieszen Van Der Cruijsen, Sandra K M" sort="Drieszen Van Der Cruijsen, Sandra K M" uniqKey="Drieszen Van Der Cruijsen S" first="Sandra K. M." last="Drieszen-Van Der Cruijsen">Sandra K. M. Drieszen-Van Der Cruijsen</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Nobilon Schering-Plough, Wim de Körverstraat 35</s1><s2>5831 AN Boxmeer</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>5831 AN Boxmeer</wicri:noRegion></affiliation></author><author><name sortKey="Rudenko, Larisa G" sort="Rudenko, Larisa G" uniqKey="Rudenko L" first="Larisa G." last="Rudenko">Larisa G. Rudenko</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Experimental Medicine, 12 Acad. Pavlov Street</s1><s2>197376 Saint Petersburg</s2><s3>RUS</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Russie</country><wicri:noRegion>197376 Saint Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Van Den Bosch, Han" sort="Van Den Bosch, Han" uniqKey="Van Den Bosch H" first="Han" last="Van Den Bosch">Han Van Den Bosch</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Nobilon Schering-Plough, Wim de Körverstraat 35</s1><s2>5831 AN Boxmeer</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>5831 AN Boxmeer</wicri:noRegion></affiliation></author><author><name sortKey="Heldens, Jacco G M" sort="Heldens, Jacco G M" uniqKey="Heldens J" first="Jacco G. M." last="Heldens">Jacco G. M. Heldens</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Nobilon Schering-Plough, Wim de Körverstraat 35</s1><s2>5831 AN Boxmeer</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>5831 AN Boxmeer</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Archives of virology</title><title level="j" type="abbreviated">Arch. virol.</title><idno type="ISSN">0304-8608</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Archives of virology</title><title level="j" type="abbreviated">Arch. virol.</title><idno type="ISSN">0304-8608</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal model</term><term>Attenuated strain</term><term>Genetic reassortment</term><term>Influenza</term><term>Vaccine</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Souche atténuée</term><term>Vaccin</term><term>Modèle animal</term><term>Grippe</term><term>Réassortiment génétique</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Vaccin</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Demonstration of the absence of neurovirulent properties of reassortant viruses contained in live attenuated influenza vaccine (LAIV) is a regulatory requirement. A mouse model was used to detect neurovirulent properties of the cold-adapted, temperature-sensitive and attenuated influenza master donor viruses (MDVs) A/Leningrad/134/ 17/57 (H2N2) and B/USSR/60/69 and derived reassortant influenza viruses. A/NWS/33 (H1N1), which is known to be neurovirulent in mice, was used as a positive control. Under conditions where the positive control virus induced symptoms of disease and showed viral replication in the upper respiratory tract as well as in the brain, replication of the influenza master donor viruses and reassortant influenza A and B viruses was limited to the upper respiratory tract where they were administered. None of the mice inoculated with MDVs or reassortant influenza viruses suffered from disease, and no virus or viral replication was observed in the brains of these mice. The results demonstrate the absence of neurovirulent properties of the MDVs and reassortant influenza viruses derived therefrom used in LAIV.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li><li>Russie</li></country></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Theo, J" sort="Theo, J" uniqKey="Theo J" first="J." last="Theo">J. Theo</name></noRegion><name sortKey="Basten, Stephanie M C" sort="Basten, Stephanie M C" uniqKey="Basten S" first="Stephanie M. C." last="Basten">Stephanie M. C. Basten</name><name sortKey="Drieszen Van Der Cruijsen, Sandra K M" sort="Drieszen Van Der Cruijsen, Sandra K M" uniqKey="Drieszen Van Der Cruijsen S" first="Sandra K. M." last="Drieszen-Van Der Cruijsen">Sandra K. M. Drieszen-Van Der Cruijsen</name><name sortKey="Glansbeek, Harrie L" sort="Glansbeek, Harrie L" uniqKey="Glansbeek H" first="Harrie L." last="Glansbeek">Harrie L. Glansbeek</name><name sortKey="Heldens, Jacco G M" sort="Heldens, Jacco G M" uniqKey="Heldens J" first="Jacco G. M." last="Heldens">Jacco G. M. Heldens</name><name sortKey="Van Den Bosch, Han" sort="Van Den Bosch, Han" uniqKey="Van Den Bosch H" first="Han" last="Van Den Bosch">Han Van Den Bosch</name><name sortKey="Voeten, M" sort="Voeten, M" uniqKey="Voeten M" first="M." last="Voeten">M. Voeten</name></country><country name="Russie"><noRegion><name sortKey="Kiseleva, Irina V" sort="Kiseleva, Irina V" uniqKey="Kiseleva I" first="Irina V." last="Kiseleva">Irina V. Kiseleva</name></noRegion><name sortKey="Rudenko, Larisa G" sort="Rudenko, Larisa G" uniqKey="Rudenko L" first="Larisa G." last="Rudenko">Larisa G. Rudenko</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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